Western Blot analysis of GP130 was performed by separating 30 µg of various whole cell extracts by 5% SDS-PAGE. Proteins were transferred to a membrane and probed with a GP130 Polyclonal Antibody (Product # PA5-28932) at a dilution of 1:1000 and a HRP-conjugated anti-rabbit IgG secondary antibody.

Titel , JLM BW-GP130 20 - Grupporträtt. Bildtext . Elsa Widén-Jonsson, blind sångerska från Östersund och Rut Lindberg för Året

CAS Article Diverse cytokines can signal through receptor complexes containing the gp130 subunit. These cytokines, which include interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and CLC (cardiotrophin-like cytokine), are implicated in inflammatory and immune responses, heart development, and fertility. Enrichment of STAT3 regulation and gp130-ligands in activated fibroblasts and macrophages led us to reason that gp130 blockade might rescue the activated program. One gp130 receptor cytokine in particular, ciliary neurotrophic factor (CNTF), a pluripotent neurocytokine, showed efficacy as a potential anti-obesogenic therapy.

Gp130

Fas 4-studie om effekten av partiell sömnbrist på kognition och IL-6-gp130-systemet hos individer med allvarlig depression IL-6 / Glycoprotein130 (GP130) roll i NASH är oklart. Blockering av IL-6 / GP130-signalering med MR16-1 förbättrad MCD-dietinducerad hepatisk steatos, men Uppsats: Correlations between unexplained infertility and single nucleotide polymorphism in the genes of leukemia inhibitory factor receptor and gp130. Gleason-Pfauter GP130 · Prisinfo Ring. Düsseldorf Tyskland.

Gp130 engagement leads to activation of Src and JAK/Tyk tyrosine kinases, as well as the STAT family of transcription factors (4, 5). IL-6 is the prototypic gp130-cytokine and binds the gp130 receptor through three conserved epitopes (sites I, II, and III), of which site III is unique to gp130-cytokines (6–9).

The ectodomain of gp130 is made up of a cytokine receptor superfamily domain as well as an immunoglobulin-like domain and three fibronectin type III-like domains. The cytoplasmic domains of neither IL-6 R nor gp130 has homology with known tyrosine kinases or other Se hela listan på academic.oup.com Summary of IL6ST (CD130, GP130) expression in human tissue. Plasma positivity. 2021-03-26 · The E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by inhibiting IL‐6/GP130/STAT3 signaling.

Glycoprotein 130 kDa (gp130) is a trans-membrane protein, which is ubiquitously expressed. It serves as the signal transduction unit of a family of cytokines: the IL-6 family.

Names & Taxonomy i. Protein 2017-02-24 · p-CD130/gp130 Antibody (A-12) is a mouse monoclonal IgG 2a κ, cited in 3 publications, provided at 200 µg/ml; specific for an epitope mapping between amino acids Ser 782 Ser 782 of gp130 of human origin Protein Mutation Frequency in Cancer. The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and therefore potentially oncogenic missense mutations (click on 'Show Cancer Mutations'). Although gp130 and its dimer partners possess no intrinsic tyrosine kinase domain, the dimerization of gp130 leads to activation of associated cytoplasmic tyrosine kinases and subsequent modification of transcription factors.

sgp130.
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Gene names i: Name:gp130 2017-02-24 2021-03-26 Rabbit polyclonal CD130 (gp130) antibody. Validated in WB, IHC, Flow Cyt and tested in Mouse, Human. Cited in 6 publication(s). Immunogen corresponding to synthetic peptide.

Exons 3-17 code for the gp130 protein, and each subdomain of the receptor is encoded by a set of exons. Cotransfection of gp130 cDNA increased the number of high-affinity binding sites, but gp130 did not directly bind IL6 (147620) or several other cytokines. Mouse IL3 (147740)-dependent pre-B cells proliferated when cultured with IL6 plus soluble IL6RA only following transfection with human gp130.
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gp130 is a ubiquitously expressed, signal‐transducing receptor that forms part of the receptor complex for several cytokines, including IL‐6, IL‐11, IL‐27, leukemia inhibitory factor, OSM, CNTF, cardiotrophin 1, and cardiotrophin‐like cytokine . gp130 was described initially in mice as a membrane‐bound glycoprotein, absent on Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors.It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. Glycoprotein gp130 has a molecular mass of 130–150 kDa; gp130 has the alternative names IL-6Rβ, CD130, and IL-6 signal transducer.